Category: Science

New discoveries, the scientific method, and all matters relating to the scientific study of the physical world

Synthetic biology for drug manufacture

For years now, I have been expecting people to use synthetic biology to make complex organic molecules like pharmaceuticals. If you splice the genes that allow some organism to make the molecule in question into another organism that is easy to cultivate, you can go from making the drug in a large and costly factory to cultivating it in a cheap batch of genetically-modified yeast.

This is now being done: Genetically Engineered Yeast Makes It Possible To Brew Morphine, A Way to Brew Morphine Raises Concerns Over Regulation, An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose.

Bill McKibben on Obama’s climate change denial

In response to the decision to let Shell drill for oil in the arctic:

This is climate denial of the status quo sort, where people accept the science, and indeed make long speeches about the immorality of passing on a ruined world to our children. They just deny the meaning of the science, which is that we must keep carbon in the ground.

We are past the point where rhetorical acknowledgment of climate change is an acceptable response. Decision-makers today need to be taking serious strides to leave most of the world’s remaining fossil fuels unburned.

U of T’s fossil fuel divestment brief

As promised, Toronto350.org got the electronic version of our final fossil fuel divestment brief to the committee members a week before our presentation: The Fossil Fuel Industry and the Case for Divestment: Update.

My friend Anne designed a great cover, using a photo from our November 2014 divestment march. I also have a version of the cover which prints perfectly at 11×17″ to serve as a cover for a bound book.

We are having paperback versions of the brief with glossy colour covers printed for the committee members, our presenters, and to deposit with the U of T library system and Library and Archives Canada. We are required to provide a legal deposit copy to them, since the work has been issued an ISBN: 978-0-9947524-0-6. The book is being printed by the Asquith Press at the Toronto Reference Library.

The next step is to adapt the brief into a kit version that can be easily employed by other campaigns. Long parts of the brief are applicable to every fossil fuel divestment campaign, such as the parts on climate science and the economics of the fossil fuel industry. Other parts need to be tailored for each institution. Particularly given that Glasgow has already succeeded using our basic text, putting in some effort to make a kit seems worthwhile.

STS-27/107

I fear that my list of project ideas, which I assemble out of an optimistic hope that the future will bring a long span of free time for such undertakings, includes an idea for a screenplay.

It would be a film in the style of Apollo 13 (technically and historically accurate, and developed with lots of research in collaboration with the people involved) based on the STS-27 and STS-107 Space Shuttle missions.

I have a bunch of ideas, but I definitely don’t have time to write such a script, given my work with Toronto350.org, photography, and being on strike as a TA at U of T.

Still, I think it could be a powerful story. Ultimately, it’s a sadder story than Apollo 13, which may limit its aesthetic and commercial appeal. Still, like any story about crewed spaceflight, this is a story of courage and dedication applied in the pursuit of scientific understanding. Twelve amazing people: 5 who lived and 7 who died.

I can provide a more detailed breakdown of the screenplay idea, if someone wants to try working on it a bit.

Update on Ebola

From The Economist:

“Body-disposal teams are credited with checking Ebola in Liberia. But such teams are often attacked in Guinea. Resistance is reported in over a third of prefectures.

…

At times last year it looked as if Ebola was under control in Guinea, the largest of the affected countries. But health workers have trouble finding the sick. Poor publicity campaigns make it less likely that they come forward. Many believe that foreigners are infecting them. The WHO is now hiring anthropologists to help co-opt local leaders.

…

Getting to zero infections will be harder the longer it takes. Heavy rains will soon make it difficult to reach remote areas. Health officials also fear complacency. America is pulling its troops out of Liberia. Others may follow. WHO officials complain of a dwindling budget. The jungles of Guinea hid the first case; as long as they hide the last ones, the outbreak is not over.